Oxalate nephropathy secondary to oxalate-rich diet and excessive vitamin C Intake


oxalate crystals
oxalate nephropathy
vitamin c



Oxalate nephropathy is a rare condition but remains an important cause of end-stage kidney disease. A 42-year-old healthy man with no comorbid was sent to a nephrologist because of significantly increased creatinine (290-836 µmol/l) within 3 months. He was found to have renal impairment when he was treated for pneumonia a few months earlier. The initial workup was unrevealing. Within a couple of weeks after the first visit, he developed acute symptomatic worsening kidney injury with nausea, vomiting and creatinine up to 836 µmol/l. Further history revealed that he had sought alternative treatment with multiple supplements containing high doses of vitamin C and foods high in oxalate precursor. A kidney biopsy confirmed oxalate nephropathy. Despite restriction of oxalate consumption, his kidney function deteriorated and he commenced on permanent hemodialysis.



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