A Journey from Thrombocytosis to Nephrology: Unmasking Amyloidosis

Abstract

CASE PRESENTATION
A 62-year-old construction worker, presented with incidental thrombocytosis of 587 × 10⁹L during a GP visit in March 2022. His symptoms also included myalgia, chronic constipation, intermittent cough with exertional dyspnoea. He also complained of frothy urine since 2019. He was referred to the nephrology team for worsening proteinuria starting in February 2024. On physical examination, blood pressure was 140/80, the patient was noted to be cachexic but with normal lung findings, no hepatosplenomegaly and no pedal oedema. There was also incidental finding of palpable cervical lymph nodes.